Resveratrol is a type of natural phenol produced by several plants.
- Anti-aging: Resveratrol mimics the antioxidant and antiaging effects of caloric restriction.
- Anti-cancer: Resveratrol inhibits the growth of human gastric carcinoma cells.
- Anti-oxidant: (antioxidant)
- Anti-angiogenic: blocks cancer blood vessel growth.
- Brain Health:
- Cognitive enhancement:
- Endothelial Health: endothelium-independent relaxations of thoracic aorta.
- Gut Health: (Digestive Health) Helps modulate gut microbiota.
- Heart Health: Resveratrol and regular aerobic exercise improves vascular functions and biomarkers related to vessel responsiveness.
- Kidney Health: Reduces renal oxidative stress.
- Vascular Health Improves vessel responsiveness (when taken in conjunction with 40mins of regular daily exercise).
- Improves biomarkers related to vascular functions.
Disease / Symptom Treatment
- Birth Defects
- Autism: Resveratrol can help prevent cellular and behavioral sensory alterations to the brain during fetal development.
- Bladder Cancer: Resveratrol induces apoptosis associated with mitochondrial dysfunction in bladder carcinoma cells.
- Cervical Cancer: Resveratrol can inhibit the occurrence and development of cervical cancer.
- Gastric Cancer: Resveratrol induces apoptosis in human gastric carcinoma.
- Pancreatic Cancer: Resveratrol induces apoptosis in pancreatic cancer cells.
- Prostate Cancer: Resveratrol enhances radiation sensitivity in prostate cancer by inhibiting cell proliferation and promoting cell senescence and apoptosis.
- Diabetes: Resveratrol may be promising for the treatment of damage in the enteric nervous system caused by diabetes (the enteric nervous system is embedded in the lining of the gastrointestinal system, beginning in the esophagus and extending down to the anus).
- Dysbiosis: prevents microbial imbalance, impaired microbiota
- Hypertension: Resveratrol can reduce renal (kidney) oxidative stress, activate nutrient-sensing signals, modulate gut microbiota, and prevent hypertension.
- Neurodegenerative Diseases
- Memory Loss: Resveratrol administration promotes complete protection against memory loss.
- Alzheimer's Disease
- Resveratrol improves of proteostasis (prevents degradation and misfolding of proteins in the brain).
- Induces neuroprotection against amyloid and tau (neuro-fibrillary tangles) pathologies.
- Promotes brain resilience and defense against neurodegeneration caused by the accumulation of aberrant proteins.
- Resveratrol administration induced complete protection against memory loss and brain pathology in mice with Alzheimer's, and also induced cognitive enhancement in healthy mice.
Title: Resveratrol Induces Brain Resilience Against Alzheimer Neurodegeneration Through Proteostasis Enhancement
Author(s): Rubén Corpas, Christian Griñán-Ferré, Eduard Rodríguez-Farré, Mercè Pallàs, Coral Sanfeliu
Institution(s): Institut d’Investigacions Biomèdiques de Barcelona (IIBB), CSIC and IDIBAPS, Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP) Madrid Spain, Faculty of Pharmacy and Food Sciences, Institut de Neurociències Universitat de Barcelona and CIBERNED, Barcelona Spain
Publication: Molecular Neurobiology
Date: June 13, 2018
Abstract: Resveratrol is a natural compound that mimics the antioxidant and antiaging effects of caloric restriction, mainly mediated through SIRT1, a deacetylase that induces longevity and neuroprotection. We aimed to analyze the effects of resveratrol on the brain status of control non-transgenic (NoTg) and AD transgenic (3xTg-AD) mice to discern the mechanisms involved in a potential inducement of resilience against age-related neurodegeneration and Alzheimer’s disease (AD). Mice were fed with a diet supplemented with 100 mg/kg of resveratrol from 2 months of age during 10 months. Resveratrol administration induced complete protection against memory loss and brain pathology in 3xTg-AD mice, and also induced cognitive enhancement in healthy NoTg mice. Resveratrol improved exploration and reduced anxiety in both mouse strains, indicative of well-being. Resveratrol reduced the presence of Aβ and p-tau pathology in the hippocampus of the 3xTg-AD mouse. Proteostasis analysis showed the following in both NoTg and 3xTg-AD mice: (i) increased levels of the amyloid-degrading enzyme neprilysin, (ii) reduction of the amyloidogenic secretase BACE1, and (iii) increase of proteasome protein levels and enhancement of proteasome activity. Resveratrol also increased AMPK protein levels, then upregulating the SIRT1 pathway, as shown by the activation of PGC-1α and CREB in both mice, resulting in further beneficial changes. Our data demonstrated that resveratrol induces cognitive enhancement and neuroprotection against amyloid and tau pathologies. Improvement of proteostasis by resveratrol, in both healthy and AD mice, suggests that it is a mechanism of brain resilience and defense against neurodegeneration caused by the accumulation of aberrant proteins.
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Title: Resveratrol induced apoptosis in human gastric carcinoma SGC‐7901 cells via activation of mitochondrial pathway
Author(s): Yining Yang, Xinen Huang, Senqing Chen, Guojian Ma, Ming Zhu, Feng Yan, Jun Yu
Institution(s): Department of Molecular Biology, Jiangsu Institute of Cancer ResearchNanjing, China
Publication: Asia-Pacific Journal of Clinical Oncology
Date: January 2018
Abstract: Background Resveratrol is a natural polyphenolic compound and its anticancer effect has been receiving considerable attention. Previous studies showed that resveratrol could inhibited the growth of human gastric carcinoma cells and apoptosis induction was an important mechanism. However, whether mitochondrial pathway was involved in resveratrol‐induced apoptosis in human gastric cancer was not very clear. Methods The cells were examined by 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2‐H‐tetrazolium bromide (MTT) assay, Annexin V/PI staining assay, mitochondrial membrane depolarization, cell morphological assessment, cytochrome c release assay, and Western blotting assay. Results In this study, we found that resveratrol induced apoptosis in human gastric carcinoma SGC‐7901 cells. Cleaved PARP was observed and caspase‐3 was activated by resveratrol. Next, the mitochondrial membrane potential of cells dissipated after the cells were treated by resveratrol. Moreover, we found that pro‐caspase 9 was downregulated and cytochrome c released from mitochondrial to the cytosol. We also found that the expression ratio of Bax/Bcl‐2 was increased in the treated cells. We finally showed that resveratrol inhibited the proliferation of SGC‐7901 xerograph in vivo. Conclusions Collectively, our findings demonstrate that resveratrol triggers apoptosis via mitochondrial pathway in SGC‐7901 cells, which provide more basis for resveratrol acting as antitumor agents in cancer therapy.
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Title: The effects of resveratrol and exercise on age and gender-dependent alterations of vascular functions and biomarkers
Author(s): Sevtap Han, Nur Banu Bal, Gökhan Sadi, Suzan E. Usanmaz, M. Orhan Uludag, Emine Demirel-Yilmaz
Institution(s): Gazi University, Faculty of Pharmacy, Department of Pharmacology, Etiler, 06330 Ankara, Turkey, Karamanoglu Mehmed Bey University, Faculty of Arts and Sciences, Department of Biological Sciences, Turkey, Ankara University, Faculty of Medicine, Department of Medical Pharmacology, Sihhiye, 06100 Ankara, Turkey
Publication: Experimental Gerontology
Date: 13 June 2018
Abstract: The purpose of this study was to determine the effects of resveratrol and regular aerobic exercise on vascular functions and biomarkers related to vessel responsiveness in an age and gender-dependent manner. The study used young (3 months) and old (12 months) male and female Wistar albino rats. Resveratrol was given in the drinking water (0.05 mg/ml; approximately 7.5 mg/kg) for 6 weeks. In the exercise group, all rats performed treadmill running at 20 m/min on a 0° incline, 40 min/day, 3 times a week, for 6 weeks. Acetylcholine-induced, endothelium-dependent and sodium nitroprusside-mediated, endothelium-independent relaxations of rat thoracic aorta and blood levels of biomarkers were separately changed by resveratrol intake and exercise-training in an age and gender-dependent manner. Antioxidant enzymes and eNOS expressions in vessels were elevated by resveratrol and exercise. Resveratrol and exercise enhanced gene expressions of non-selective PDE1, 2, 3 and cAMP selective PDE4 but not cGMP selective PDE5 in the aorta. In addition, the aortic mRNA expression of inflammation markers were altered by resveratrol and exercise-training. The results of the study demonstrated that vessel responsiveness and biomarkers related to vascular functions were altered by resveratrol consumption and exercise-training in an age and gender-dependent manner.
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Title: Resveratrol promotes neuroprotection and attenuates oxidative and nitrosative stress in the small intestine in diabetic rats
Author(s): Paulo Emilio Botura Ferreira, Evandro José Beraldi, Stephanie Carvalho Borges, Maria Raquel Marçal Natali, Nilza Cristina Buttow
Institution(s): Federal University of Pampa, KM 592 BR 472 Road, Uruguaiana, Rio Grande do Sul, 97500-970, Brazil, Departament of Morphological Sciences, State University of Maringá, 5790 Colombo Avenue, Maringá, Paraná, 87020-900, Brazil
Publication: Biomedicine & Pharmacotherapy
Date: 12 June 2018
Abstract: Damages to the enteric nervous system caused by diabetes mellitus (DM) are frequently attributed to oxidative and nitrosative stress. We aimed to investigate the effect of Resveratrol (RSV) (10 mg/kg) on oxidative and nitrosative stress in the intestinal wall and morphoquantitative aspects of the myenteric plexus of the duodenum, jejunum and ileum in diabetic rats. Twenty-four rats were distributed into four groups (n = 6/group): control (C group), control treated with RSV (CR group), diabetic (D group), and diabetic treated with RSV (DR group) for 120 days. Immunohistochemical staining techniques for the general neuronal population, nitrergic and calretinin neuronal subpopulations, enteric glial cells and glial fibrillary acid protein were performed in the myenteric plexus. Furthermore, parameters of oxidative and nitrosative stress were analyzed in the intestinal wall. RSV attenuated oxidative and nitrosative stress and prevented neuronal loss and hypertrophy of the HuC/D-IR, nNOS-IR and CALR-IR neuronal subpopulations in the DR group compared with the D group (P < 0.05). In addition, RSV prevented the increase in glial fibrillary acid protein fluorescence in the DR group compared with the D (P < 0.05). These results suggest that RSV has antioxidant and neuroprotective effects in myenteric plexus in rats with experimental DM.
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Title: Resveratrol Prevents Cellular and Behavioral Sensory Alterations in the Animal Model of Autism Induced by Valproic Acid
Author(s): Mellanie Fontes-Dutra, Júlio Santos-Terra, Iohanna Deckmann, Gustavo Brum Schwingel, Gustavo Della-Flora Nunes, Mauro Mozael Hirsch, Guilherme Bauer-Negrini, Rudimar S. Riesgo, Victorio Bambini-Júnior, Cecília Hedin-Pereira, and Carmem Gottfried
Institution(s): Translational Research Group in Autism Spectrum Disorders (GETTEA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil, Department of Biochemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil, National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Department of Biochemistry, University of Buffalo, The State University of New York, New York, NY, United States, Child Neurology Unit, Clinical Hospital of Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil, School of Pharmacology and Biomedical Sciences, University of Central Lancashire, Preston, United Kingdom, Institute of Biophysics Carlos Chagas Filho and Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil
Publication: frontiers in Synaptic Neuroscience
Date: May 22 2018
Abstract: Autism spectrum disorder (ASD) is characterized by impairments in both social communication and interaction and repetitive or stereotyped behaviors. Although its etiology remains unknown, genetic and environmental risk factors have been associated with this disorder, including the exposure to valproic acid (VPA) during pregnancy. Resveratrol (RSV) is an anti-inflammatory and antioxidant molecule known to prevent social impairments in the VPA animal model of autism. This study aimed to analyze the effects of prenatal exposure to VPA, as well as possible preventive effects of RSV, on sensory behavior, the localization of GABAergic parvalbumin (PV+) neurons in sensory brain regions and the expression of proteins of excitatory and inhibitory synapses. Pregnant rats were treated daily with RSV (3.6 mg/kg) from E6.5 to E18.5 and injected with VPA (600 mg/kg) in the E12.5. Male pups were analyzed in Nest Seeking (NS) behavior and in whisker nuisance task (WNT). At P30, the tissues were removed and analyzed by immunofluorescence and western blotting. Our data showed for the first time an altered localization of PV+-neurons in primary sensory cortex and amygdala. We also showed a reduced level of gephyrin in the primary somatosensory area (PSSA) of VPA animals. The treatment with RSV prevented all the aforementioned alterations triggered by VPA. Our data shed light on the relevance of sensory component in ASD and highlights the interplay between RSV and VPA animal model as an important tool to investigate the pathophysiology of ASD.
Title: Resveratrol significantly inhibits the occurrence and development of cervical cancer by regulating PLSCR1
Author(s): Yang Qiu and Xiaoyu Wang
Institution(s): Department of Gynecology, the First Affiliated Hospital of Jinan University, Guangzhou, PR China
Publication: Allied Academies: Biomedical Research
Date: November 2017
Abstract: Cervical cancer is currently the most common female malignancies, and resveratrol is a polyphenol isolated from the skins of grapes that has been reported to significantly alter the cellular physiology of tumor cells, as well as block the process of initiation and progression. Little is known about the role of PLSCR1 in the occurrence and development of cervical cancer. Here, we demonstrated that resveratrol significantly inhibited both the growth of HeLa cells and expression of PLSCR1, which can be recovered by gain of function of PLSCR1. These results suggest that resveratrol mediated cell growth inhibition can be regulated by PLSCR1.
Title: Resveratrol Prevents the Development of Hypertension Programmed by Maternal Plus Post-Weaning High-Fructose Consumption Through Modulation of Oxidative Stress, Nutrient-Sensing Signals, and Gut Microbiota.
Author(s): Tain YL, Lee WC, Wu KLH, Leu S, and Chan JYH
Institution(s): Department of Pediatrics, Department of Urology, Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Kaohsiung, Taiwan.
Publication: Molecular Nutrition & Food Research
Date: April 30 2018
Abstract: High-fructose (HF) intake, oxidative stress, nutrient-sensing signals, and gut microbiota dysbiosis are closely related to the development of hypertension. We investigated whether resveratrol can prevent hypertension induced by maternal plus post-weaning HF diets in adult offspring via the above-mentioned mechanisms.Female Sprague-Dawley rats received either a normal (ND) or 60% high-fructose (HF) diet during gestation and lactation. Male offspring were assigned to five groups (maternal diet/post-weaning diet; n = 8/group): ND/ND, ND/HF, HF/ND, HF/HF, and HF/HF+ Resveratrol. Resveratrol (50 mg/L) was administered in drinking water from weaning to three months of age. We found that HF/HF induced hypertension in adult offspring. Maternal HF diet altered gut microbiota composition in adult offspring, including decreasing the abundance of genera Bacteroides, Dysgonomonas, and Turicibacter, while increasing phylum Verrucomicrobia and Akkermansia muciniphila. Additionally, HF/HF diets increased oxidative stress and decreased renal mRNA expression of Prkaa2, Prkag2, Ppara, Pparb, Ppargc1a, and Sirt4. Resveratrol reduced renal oxidative stress, activated nutrient-sensing signals, modulated gut microbiota, and prevented associated HF/HF-induced programmed hypertension. Targeting oxidative stress, nutrient-sensing signals, and gut microbiota by resveratrol might be a useful therapeutic strategy for treatment of hypertension induced by excessive consumption of fructose in the adult rat offspring.
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