Piperine is an alkaloid that can be extracted from black pepper.
- Cytoprotective: protects cells against harmful agents.
- Chemopreventive effect by modulating lipid peroxidation and augmenting antioxidant defense system.
Disease / Symptom Treatment
- Effectively suppresses lung cancer.
- Cancer treatment
- Resveratrol and piperine enhance radiosensitivity of tumor cells.
Title: Cytoprotective effect of piperine against benzo[a]pyrene induced lung cancer with reference to lipid peroxidation and antioxidant system in Swiss albino mice Author links open overlay panel
Author(s): K Selvendiran, J. Prince Vijeya Singh, K. Baba Krishnan, D Sakthisekaran
Institution(s): Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai 600 113, India, Department of Pathology, Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
Date: Feb 2003
Abstract: The cytoprotective effect of piperine on benzo[a]pyrene (B[a]P) induced experimental lung cancer was investigated in male Swiss albino mice. Oral administration of piperine (100 mg/kg body wt.) effectively suppressed lung cancer initiated with B[a]P as revealed by the decrease in the extent of lipid peroxidation with concomitant increase in the activities of enzymatic antioxidants (superoxide dismutase, catalase and glutathione peroxidase) and non-enzymatic antioxidant (reduced glutathione, vitamin E and vitamin C) levels when compared to lung cancer bearing animals. Our data suggest that piperine may extend its chemopreventive effect by modulating lipid peroxidation and augmenting antioxidant defense system.
Citations: ↩ ↩ ↩
Title: Resveratrol and piperine enhance radiosensitivity of tumor cells
Author(s): Tak, Jean-Kyoung; Lee, Jun-Ho; Park, Jeen-Woo
Publication: Korean Society for Biochemistry and Molecular Biology
Date: Feb 2003
Abstract: The use of ionizing radiation (IR) is essential for treating many human cancers. However, radioresistance markedly impairs the efficacy of tumor radiotherapy. IR enhances the production of reactive oxygen species (ROS) in a variety of cells which are determinant components in the induction of apoptosis. Much interest has developed to augment the effect of radiation in tumors by combining it with radiosensitizers to improve the therapeutic ratio. In the current study, the radiosensitizing effects of resveratrol and piperine on cancer cells were evaluated. Cancer cell lines treated with these natural products exhibited significantly augmented IR-induced apoptosis and loss of mitochondrial membrane potential, presumably through enhanced ROS generation. Applying natural products as sensitizers for IR-induced apoptotic cell death offers a promising therapeutic approach to treat cancer.