A new study from the University of Gothenburg in Sweden and University Magna Grecia in Italy shows for the first time that Bermagot Polyphenols have a direct effect on bone cell regulation and may be a new tool against the breakdown of bone tissue.

Fruit consumption can have a positive effect on bone mineral density. Citrus fruits are particularly important in this role due to their high polyphenol content. However, to date, the effects of polyphenols, as nutraceuticals, on bone cell metabolism have scarcely been studied.[1]

The Bergamot Orange (Citrus bergamia Risso) is an ancestral citrus fruit which has a notably high concentration of flavonoids.


  1. Title: Bergamot Polyphenol Fraction Exerts Effects on Bone Biology by Activating ERK 1/2 and Wnt/β-Catenin Pathway and Regulating Bone Biomarkers in Bone Cell Cultures
    Author(s): Arturo Pujia, Cristina Russo, Samantha Maurotti, Roberta Pujia, Vincenzo Mollace, Stefano Romeo, and Tiziana Montalcini
    Institution(s): Department of Medical and Surgical Science, University Magna Grecia, 88100 Catanzaro, Italy; Department of Health Science, University Magna Grecia, 88100 Catanzaro, Italy; Department of Molecular and Clinical Medicine, University of Gothenburg, 40530 Gothenburg, Sweden; Department of Clinical and Experimental Medicine, Nutrition Unit, University Magna Grecia, 88100 Catanzaro, Italy
    Publication: The Journal of Nutritional Biochemistry
    Date: 14 September 2018
    Abstract: Epidemiological studies show that fruit consumption may modulate bone mineral density. However, data regarding the effect of the Citrus bergamia Risso (Bergamot orange), a citrus fruit containing a high concentration of flavonoids, on bone health are still lacking. In this study, we investigated the effects of Bergamot polyphenols on the Wnt/β-catenin pathway in two distinct bone cell types (Saos-2 and MG63). Findings showed that exposure to 0.01 and 0.1 mg/mL doses upregulate β-catenin expression (p = 0.001), osteoblast differentiation markers (e.g., RUNX2 and COL1A), and downregulate RANKL (p = 0.028), as compared to the control. Our results highlight, for the first time, that Bergamot polyphenols act on bone cells through the β-catenin pathway. In vivo studies are necessary to fully understand Bergamot’s role against bone resorption.
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