Eucalyptus is a diverse genus of flowering trees and shrubs.

Healing Properties

Disease / Symptom Treatment

  • Parasites:
    • Toxoplasmosis: Toxoplasmosis is a disease caused by the protozoan parasite Toxoplasma gondii (T. gondii). Eucalyptus may be a useful candidate for treating Toxoplasma infection.[1]
      • The increased weight of liver and spleen, due to infection, was reduced by treatments.[1]
      • Eucalyptus possess anti-T. gondii activities in vitro and in vivo, in addition, Eucalyptus shows antioxidant activity.[1]

Sources

  1. Title: Effects of Aloe vera and Eucalyptus methanolic extracts on experimental toxoplasmosis in vitro and in vivo
    Author(s): Bahareh Mirzaalizadeh, Mehdi Sharif, Ahmad Daryani, Mohammad Ali Ebrahimzadeh, Mehryar Zargari, Shahabeddin Sarvi, Saeed Mehrzadi, Mohammad Taghi Rahimi Zahra Mirabediny, Monireh Golpour, Mahbobeh Montazeri
    Institution(s): oxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran; Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran; Department of Parasitology, School of Medicine, Sari Branch, Islamic AZAD University, Sari, Iran; Department of Parasitology and Mycology, Sari Medical School, Mazandaran University of Medical Sciences, Sari, Iran; Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran; Department of Biochemistry, Biophysics and Genetic, Cellular and Molecular Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran; Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran;School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran;Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran
    Publication: Experimental Parasitology
    Date: September 2018
    Abstract: Toxoplasmosis is a worldwide disease caused by the protozoan parasite Toxoplasma gondii (T. gondii), which is most commonly treated by pyrimethamine and sulfadiazine. However, this treatment presents several adverse side effects; Thus, new drugs with lower toxicities are urgently needed. In this study the anti-T. gondii activity of A. vera and Eucalyptus extracts were evaluated in vitro using a MTT (3-(4, 5-dimethylthiazol-2-yl) 2, 5-diphenyltetrazolium bromide) assay and in vivo by measuring the survival rates of mice infected with 2 × 103 tachyzoites of RH strain of T. gondii and then injected intraperitoneally by different concentrations of extracts for 4 days. Biochemical parameters such as Ferric Reducing Antioxidant Potential (FRAP) and malondialdehyde (MDA) assay were also evaluated. As results, in the in vitro assay, the IC50 values were 13.2, 24.7, 2.63 μg/ml, and the selectivity indexes were 3.3, 2.4, 3.03 for the A. vera, Eucalyptus and pyrimethamine, respectively. The mice treated with Eucalyptus showed a better survival rate than others (P < 0.05). The increased weight of liver and spleen, due to infection, was reduced by treatments. In FRAP assay Eucalyptus showed a better antioxidant activity than the other extracts. MDA levels in both liver and spleen were reduced by treatment. The results show that A. Vera and Eucalyptus possess anti-T. gondii activities in vitro and in vivo, in addition, Eucalyptus shows antioxidant activity with a higher survival rate. Therefore, Eucalyptus may be a useful candidate for treating Toxoplasma infection. Moreover, further studies are required to investigate the fractionations of this plant against T. gondii.
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