- Protects Skin from UV Damage: Djulis Extract can protect skin against UV-induced damage and this protection is mainly from contributions of rutin and chlorogenic acid.
Disease / Symptom Treatment
- Ameliorates Dermal Damage: Protects skin from UV-induced damage.
Title: Djulis (Chenopodium formosanum Koidz.) Water Extract and Its Bioactive Components Ameliorate Dermal Damage in UVB-Irradiated Skin Models
Author(s): Yong-Han Hong, Ya-Ling Huang, Yao-Cheng Liu, and Pi-Jen Tsai
Institutions: Department of Nutrition, I-Shou University, Kaohsiung, Taiwan, Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung, Taiwan, Department of Food Science, National Pingtung University of Technology and Science, Pingtung, Taiwan
Publication: BioMed Research International
Date: 10 October 2016
Abstract: Dermal photo-aging is a condition of skin suffering inappropriate ultraviolet (UV) exposure and exerts inflammation, tissue alterations, redness, swelling, and uncomfortable feelings. Djulis (Chenopodium formosanum Koidz.) is a cereal food and its antioxidant and pigment constituents may provide skin protection from photo-aging, but it still lacks proved experiments. In this study, protective effects of djulis extract (CFE) on UVB-irradiated skin were explored. The results showed that HaCaT cells with 150 μg/mL CFE treatment had higher survival and less production of interleukin- (IL-) 6, matrix metalloprotease- (MMP-) 1, and reactive oxygen species (ROS) in UVB-irradiated conditions. Subsequently, in animal studies, mice supplemented with CFE (100 mg/kg BW) were under UVB irradiation and had thinner epidermis and lower IL-6 levels in skin layer. These data demonstrate that bioactive compounds possessing the potency of antiphotoaging exist in CFE. Following that, we found rutin and chlorogenic acid (10–100 μM) could significantly increase cell viability and decrease the production of IL-6 in UVB models. Additionally, djulis pigment-betanin has no effect of increasing cell viability in this study. Our findings suggest CFE can protect skin against UV-induced damage and this protection is mainly from contributions of rutin and chlorogenic acid.
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