delta-Tocotrienol is a member of the vitamin E family.
- δTE-13′-COOH (13’-carboxychromanols) are a metabolite from δ-Tocotrienol (delta-tocotrienol).
- δT-13’-COOH competitively and potently inhibits cyclooxygenases (COX-1 and COX-2) and is much stronger than tocopherols or short-chain metabolites in these effects.
- Inhibition of COX can provide relief from the symptoms of inflammation and pain.
- Non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, exert their effects through inhibition of COX.
- Shown to significantly suppressed the growth and multiplicity of colon tumors in mice.
- 13′-COOHs have anti-inflammatory and anticancer activities
- may contribute to in vivo anticancer effect of vitamin E forms and are promising novel cancer prevention agents.
Disease / Symptom Treatment
- Colon Cancer: